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Two doses is only 2 weeks in, which is not enough time to confirm GI tolerance or to settle into your titration step

The extracellular exposure of DNA in NETs makes them susceptible to degradation by DNase, which enzymatically cleaves the DNA backbone, resulting in the disassembly of the intricate web-like structures

Ochi H, Horiuchi I, Araki n, Toda T, Araki T, Sato K, Murai H, Osoegawa M, Yamada T, Okamura K, Ogino T, Mizumoto K, Yamashita H, Saya H, Kira J

Intramuscular (IM) injections of hydroxocobalamin are the most reliable method of ensuring adequate B12 levels, particularly in patients with confirmed deficiency or neurological symptoms